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Hek293 coca cola8/26/2023 ![]() ![]() Since 2015, there have been seven HEK-derived products approved by the FDA ( Table 1). Some recombinant proteins are made in HEK293 due to requirements in PTMs which cannot be met in CHO, and most therapeutic viral vectors are produced in HEK293. However, not all biopharmaceutical products can be produced in CHO. Complex biologics such as antibodies, growth and clotting factors require complex PTMs to ensure product stability and potency. ![]() The use of mammalian production cells enables biologics with complex post-translational modifications (PTMs) to be produced. Production of complex biopharmaceutical products rely heavily on mammalian cell lines, with most therapeutic biopharmaceuticals produced in the Chinese hamster ovary (CHO) cells ( Lalonde and Durocher, 2017). ![]()
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